NeuroSense develops combined therapies to treat complex neurodegenerative diseases. In addition to PrimeC for ALS, which is currently undergoing clinical trials, we are expanding our pipeline and have begun preclinical research into Alzheimer’s and Parkinson’s diseases.
PrimeC is a novel formulation composed of unique doses of two FDA-approved drugs, Ciprofloxacin and Celecoxib, which aim to synergistically inhibit the progression of ALS by aiming to regulate microRNA synthesis, reduce neuroinflammation, and influence iron accumulation.
There are many shared pathways between Parkinson’s disease and ALS, such as neuroinflammation, protein aggregation, mitophagy, excitotoxicity, oxidative stress, iron accumulation, and dysregulation of miRNAs. Therefore, we are working to develop a drug for Parkinson’s based on the foundations of our drug, PrimeC, for ALS. We have initiated the pre-clinical stage, testing StabiliC in in-vivo models of Parkinson’s, assessing morphological and functional effects, and plan to move into the clinical phase during 2023.
Due to the many shared pathways between neurodegenerative diseases, the hypothesis is that a disease-modifying drug for one, can lay the foundations for effective drugs for other neurodegenerative diseases. Therefore, we are working to develop a drug for Alzheimer’s based on the foundations of PrimeC. We have initiated the pre-clinical stage, testing CogniC in in-vitro models representing Alzheimer’s disease pathologies, and plan to continue into the clinical phase during 2022.